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       胡日查

          教授,博士生导师

          办公室:化学楼420

          电话:18047181136

          邮箱:hbaigude@imu.edu.cn


教育背景

1987-1991:内蒙古师范大学生物系读本科,获理学学士学位

1996-1999:内蒙古大学生命科学学院读硕士,获理学硕士学位

2001-2004:日本帝京科学大学环境与材料科学系读博士,获理学博士学位

工作经历

1999-2001:2022世界杯预选赛买球,讲师

2004-2005:日本北见工业大学,博士后研究员

2005-2008:美国University of Massachusetts Medical School,博士后研究员

2008-2012:美国Sanford Burnham Prebys Medical Discovery Institute,专职研究员

2012-至今:2022世界杯预选赛买球,教授

研究领域

核酸类药物递送;脂质体及脂质纳米微球;天然多糖及蒙药作用机制;

研究项目

  1. 国家自然科学基金委员会,面上项目,21875124,基于凝胶多糖的多功能细胞支架的设计及其抗肿瘤免疫治疗活性的研究,2019-01-2022-1265万,在研,主持;

  2. 国家自然科学基金委员会,地区科学项目,32160231双配体功能化LNP载体的设计及其胶质细胞靶向siRNA递送研究,2022-01-2025-1234万,在研,主持;

  3. 国家自然科学基金委员会,面上项目,21375058,利用亲和光交联和纳米微粒检测microRNA靶基因的研究,2014-01-2017-1280万,已结题,主持;

  4. 国家自然科学基金委员会,地区科学项目,21364006,利用分支多肽型纳米微粒靶向性传送siRNA的研究,2014-01-2017-1250万,已结题,主持;

  5. 国家自然科学基金委员会,地区科学项目,81560568,降血脂活性天然产物荜茇宁特异性靶标的确定及其作用机理研究,2016-01-2019-1242万,已结题,主持;

  6. 内蒙古自治区自然科学基金项目,2021MS02009,基于多糖型纳米微球的靶向性siRNA药物载体的设计,2021-01-2023-127万,在研,主持;

  7. 内蒙古自治区科技计划项目,额尔顿乌日勒和萨乌日勒对神经再生相关基因表达的调控作用研究,2015-01-201-/12,主要参与人,已结题;

  8. 内蒙古自治区自然科学基金项目,萨乌日勒优化方对神经细胞的保护作用机理研究,2017-01-2019-12,主要参与人,已结题;

 

奖励

中共内蒙古自治区委员会组织部2013年、2018年“草原英才”奖

内蒙古自治区蒙医药学会脑病专业委员会2018年学术年会论文一等奖

中国民族医药学会2019年科学技术奖二等奖

兼职

内蒙古自治区蒙医药学会脑病专业委员会委员

中国民族医药学会脑病分会常务理事

学术期刊BioMed Research International学术编辑

研究成果(论文)

2012-至今

1.      Bao Q, Ganbold T, Qiburi Q, Bao M, Han S, Baigude H, AMP functionalized curdlan nanoparticles as a siRNA carrier: Synthesis, characterization and targeted delivery via adenosine A2B receptor, Int. J. Biol. Macromol., 2021, 193, 866-873, doi: 10.1016/j.ijbiomac.2021.10.138. (通讯作者)

2.      Muqier M, Xiao H, Yu X, Li Y, Bao Q, Han S, Baigude H. Synthesis of PEGylated cationic curdlan derivatives with enhanced biocompatibility. J Biomater Sci Polym Ed. 2022 33(4):465-480, doi: 10.1080/09205063.2021.1992589. (通讯作者)

3.      Hai Xiao, Han S, Baigude H. Regulation of microglia polarization via mannose receptor-mediated delivery of siRNA by ligand-functionalized DoGo LNP. RSC Adv., 2021, 11, 32549. doi: 10.1039/d1ra04293a (通讯作者)

4.      Bao M, Ehexige E, Xu J, Ganbold T, Han S, Baigude H. Oxidized curdlan activates dendritic cells and enhances antitumor immunity. Carbohydr Polym. 2021, 264:117988. doi: 10.1016/j.carbpol.2021.117988. (通讯作者)

5.      Qiburi Q, Temuqile T, Baigude H. Synergistic Regulation of Microglia Gene Expression by Natural Molecules in Herbal Medicine. Evidence-Based Complementary and Alternative Medicine. 2021: 9920364. doi.org/10.1155/2021/9920364 (通讯作者)

6.      Liao C, Han Y, Chen Z, Baigude H. The extract of black cumin, licorice, anise, and black tea alleviates OVA-induced allergic rhinitis in mouse via balancing activity of helper T cells in lung. Allergy Asthma Clin Immunol. 2021 Sep 7;17(1):87. doi: 10.1186/s13223-021-00587-6. PMID: 34493326; PMCID: PMC8424864. (通讯作者)

7.      Su Z, Ganbold T, Baigude H. Analysis and Identification of Tumorigenic Targets of MicroRNA in Cancer Cells by Photoreactive Chemical Probes. Int J Mol Sci. 2020 Feb 24;21(4):1545. doi: 10.3390/ijms21041545. (通讯作者)

8.      Ganbold T, Bao Q, Zandan J, Hasi A, Baigude H. Modulation of Microglia Polarization through Silencing of NF-κB p65 by Functionalized Curdlan Nanoparticle-Mediated RNAi. ACS Appl Mater Interfaces. 2020 Mar 11;12(10):11363-11374. doi: 10.1021/acsami.9b23004. (通讯作者)

9.      Ehexige E, Bao M, Bazarjav P, Yu X, Xiao H, Han S, Baigude H. Silencing of STAT3 via Peptidomimetic LNP-Mediated Systemic Delivery of RNAi Downregulates PD-L1 and Inhibits Melanoma Growth. Biomolecules. 2020 Feb 12;10(2):285. doi: 10.3390/biom10020285. (通讯作者)

10.  Erdene-Ochir T, Ganbold T, Zandan J, Han S, Borjihan G, Baigude H. Alkylation enhances biocompatibility and siRNA delivery efficiency of cationic curdlan nanoparticles. Int J Biol Macromol. 2020 Jan 15;143:118-125. doi: 10.1016/j.ijbiomac.2019.12.048. (通讯作者)

11.  Su Z, Erdene-Ochir T, Ganbold T, Baigude H. Design of curdlan-based pH-sensitive polymers with endosome buffering functionality for siRNA delivery. Int J Biol Macromol. 2020 Mar 1;146:773-780. doi: 10.1016/j.ijbiomac.2019.10.129. (通讯作者)

12.  Qiburi Q, Ganbold T, Bao Q, Da M, Aoqier A, Temuqile T, Baigude H. Bioactive components of ethnomedicine Eerdun Wurile regulate the transcription of pro-inflammatory cytokines in microglia. J Ethnopharmacol. 2020 Jan 10;246:112241. doi: 10.1016/j.jep.2019.112241. (通讯作者)

13.  Ehexige E, Ganbold T, Yu X, Han S, Baigude H. Design of Peptidomimetic Functionalized Cholesterol Based Lipid Nanoparticles for Efficient Delivery of Therapeutic Nucleic Acids. Molecules. 2019 Sep 19;24(18). pii: E3413. doi: 10.3390/molecules24183413. (通讯作者)

14.  Wang X, Qi Y, Liu L, Ganbold T, Baigude H, Han J. Preparation and cell activities of lactosylated curdlan-triornithine nanoparticles for enhanced DNA/siRNA delivery in hepatoma cells. Carbohydr Polym. 2019 Dec 1;225:115252. doi: 10.1016/j.carbpol. 2019.115252. Epub 2019 Aug 27. (通讯作者)

15.  Ganbold T, Han S, Hasi A, Baigude H. Receptor-mediated delivery of therapeutic RNA by peptide functionalized curdlan nanoparticles. Int J Biol Macromol. 2019 Apr 1;126:633-640. doi: 10.1016/j.ijbiomac.2018.12.152. Epub 2018 Dec 18. (通讯作者)

16.  Chen X, Tian F, Li M, Xu H, Cai M, Li Q, Zuo X, Wang H, Shi X, Fan C, Baigude H, Shan Y. Size-Independent Transmembrane Transporting of Single Tetrahedral DNA Nanostructures. Glob Chall. 2019 Nov 20;4(3):1900075. doi: 10.1002/gch2.201900075. PMID: 32140254; PMCID: PMC7050086.

17.  Ganbold T, Baigude H. Design of Mannose-Functionalized Curdlan Nanoparticles for Macrophage-Targeted siRNA Delivery. ACS Appl Mater Interfaces. 2018, 10(17):14463-14474. (通讯作者)

18.  Han S, Ganbold T, Bao Q, Yoshida T, Baigude H. Sugar Functionalized Synergistic Dendrimers for Biocompatible Delivery of Nucleic Acid Therapeutics. Polymers. 2018, 10(9), 1034 (通讯作者)

19.  Gaowa S, Bao N, Da M, Qiburi Q, Ganbold T, Chen L, Altangerel A, Temuqile T, Baigude H. Traditional Mongolian medicine Eerdun Wurile improves stroke recovery through regulation of gene expression in rat brain. J Ethnopharmacol. 2018, 222:249-260. (通讯作者)

20.  Dong J, Hu J, Baigude H, Zhang H. A novel ferrocenyl-naphthalimide as a multichannel probe for the detection of Cu(ii) and Hg(ii) in aqueous media and living cells. Dalton Trans. 2018 Jan 2;47(2):314-322. doi: 10.1039/c7dt03982d.

21.   Gao X, Hai X, Baigude H, Guan W, Liu Z. Fabrication of functional hollow microspheres constructed from MOF shells: Promising drug delivery systems with high loading capacity and targeted transport. Sci Rep. 2016 Nov 23;6:37705. doi: 10.1038/srep37705.

22.  Gerile G, Ganbold T, Li Y, Baigude H. Head group configuration increases biocompatibility of cationic lipids for nucleic acids delivery, Journal of Materials Chemistry B, 2017, 5: 5597-5607. (通讯作者)

23.  Tong Y, Ganbold T, Baigude H. Synthesis of Amphoteric Curdlan Derivatives for Delivery of Therapeutic Nucleic Acids, Carbohydrate Polymers, 2017, 175: 739-745. (通讯作者)

24.  Han J, Wang X, Liu L, Li D, Suyaola S, Wang T, Baigude H. "Click" chemistry mediated construction of cationic curdlan nanocarriers for efficient gene delivery. Carbohydr Polym. 2017, 163:191-198. (通讯作者)

25.  Ganbold T, Gerile G, Xiao H, Baigude H. Efficient in vivo siRNA delivery by stabilized D-peptide-based lipid nanoparticles. RSC Adv., 2017, 7, 8823-8831. (通讯作者)

26.  Hou X, Ganbold T, Baigude H. Synthesis of biocompatible amino acid-modified poly(acrylic acid) derivatives for intracellular gene delivery, International Journal of Polymeric Materials and Polymeric Biomaterials, 2017, 67:3, 174-180 (通讯作者)

27.  Altangerel A, Cai J, Liu L, Wu Y, Baigude H, Han J. PEGylation of 6-amino-6-deoxy curdlan for efficient in vivo siRNA delivery. Carbohydr Polym. 2016, 141:92-8. (通讯作者)

28.  Xiao H, Altangerel A, Gerile G, Wu Y, Baigude H. Design of Highly Potent Lipid-Functionalized Peptidomimetics for Efficient in Vivo siRNA Delivery. ACS Appl Mater Interfaces. 2016, 8(12):7638-45. (通讯作者)

29.  Wu Y, Cai J, Han J, Baigude H. Cell Type-Specific Delivery of RNAi by Ligand-Functionalized Curdlan Nanoparticles: Balancing the Receptor Mediation and the Charge Motivation. ACS Appl Mater Interfaces. 2015, 7(38):21521-8.(通讯作者)

30.  Han J, Cai J, Borjihan W, Ganbold T, Rana TM, Baigude H. Preparation of Novel Curdlan Nanoparticles for Intracellular siRNA Delivery. Carbohydrate Polymers, 2015, 117, 324–330.(通讯作者)

31.  Yu S, Gao X, Baigude H, Hai X, Zhang R, Gao X, Shen B, Li Z, Tan Z, Su H. Inorganic nanovehicle for potential targeted drug delivery to tumor cells, tumor optical imaging. 2015, ACS Appl Mater Interfaces. 7(9):5089-96.

32.  McCarroll JA, Dwarte T, Baigude H, Dang J, Yang L, Erlich RB, Kimpton K, Teo J, Sagnella SM, Akerfeldt MC, Liu J, Phillips PA, Rana TM, Kavallaris M. Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer. Oncotarget. 2014, 6(14):12020-34.

33.  Baigude H, Rana TM. Strategies to antagonize miRNA functions in vitro and in vivo. Nanomedicine (Lond), 2014, 9(16), 2545-55.

34.  Sarnaizul E, Borjihan G, Baigude H et al. LC analysis and pharmacokinetic study of synthetic piperlonguminine in rat plasma after oral administration. Biomed Chromatogr. 2013, 27(7), 821-4.

2012年以前:

1.      Huricha Baigude, Jie Su, Joshua McCarroll, and Tariq M. Rana (2013). In Vivo Delivery of RNAi by Reducible Interfering Nanoparticles (iNOPs). ACS Med. Chem. Lett., DOI: 10.1021/ml4001003.

2.      Huricha Baigude, Ahsanullah, Zhonghan Li, Ying Zhou, and Tariq Rana (2012). miR-TRAP: a Benchtop Chemical Biology Strategy to Identify microRNA Targets. Angew. Chem. Int. Ed. 51, 5880 -5883.

3.      Huricha Baigude, Tariq Rana (2012). Interfering nanoparticles for microRNA delivery. Methods in Enzymology. 509, 339-53.

4.      Huricha Baigude*, Joshua McCarroll*, Chao-shun Yang, Tariq M. Rana (2010). Nanotubes Functionalized with Lipids and Natural Amino Acid Dendrimers: A New Strategy to Create Nanomaterials for Delivering Systemic RNAi.Bioconjugate Chem.21, 56-63.

5.      Huricha Baigude, Tariq M. Rana (2009). Delivery of Therapeutic RNAi by Nanovehicles. ChemBioChem 10, 2449-2454.

6.      Huricha Baigude, Joshua McCarroll, Chao-shun Yang, Pamela M. Swain, and Tariq M. Rana (2007). Design and Creation of New Nanomaterials for Therapeutic RNAi. ACS Chemical Biology, 2(4), 237-241.

7.      Huricha Baigude, Kaname Katsuraya, Shinichi Tokunaga, Naohiko Fujiwara, Masaya Satoyama, Tomohiro Magome, Kohsaku Okuyama, Gereltu Borjihan, Toshiyuki Uryu (2005). Synthesis of an oligosaccharide-polylysine dendrimer with reducing sugar terminals leading to acquired immunodeficiency syndrome vaccine preparation. J. Polym. Sci. A Polym. Chem., 43, 2195-2206.

8.      Huricha Baigude, Kaname Katsuraya, Kohsaku Okuyama, Naoki Kariya, and Toshiyuki Uryu (2004). Synthesis of HIV Vaccine Model Based on Lactose-Functionalized Poly(lysine) Dendrimer Scaffold. Sen’i Gakkaishi, 60, 118-124.

9.      Huricha Baigude, Kaname Katsuraya, Kohsaku Okuyama, Kenichi, Hatanaka, Emi Ikeda, Naokazu Shibata, and Toshiyuki Uryu (2004). Synthesis of Spherical and Hemispherical Sugar-Containing Poly(ornithine) Dendrimers. J. Polym. Sci. A Polym. Chem., 42, 1400-1414.

10.  Huricha Baigude, Kaname Katsuraya, Kohsaku Okuyama, and Toshiyuki Uryu (2004). Synthesis of Structurally-Controlled HIV Vaccine Model Having Glyco-Peptide Dendrimer Scaffolds” Macromol. Chem. Phys., 205, 684-691. Cited by 31

11.  Huricha Baigude, Kaname Katsuraya, Kohsaku Okuyama, Shinichi Tokunaga, and Toshiyuki Uryu (2003). Synthesis of Sphere-Type Monodispersed Oligosaccharide Polypeptide Dendrimers. Macromolecules, 36, 7100-7106.

12.  Huricha Baigude, Kaname Katsuraya, Kohsaku Okuyama, Yoshihide Yachi, Shoma Sato, and Toshiyuki Uryu (2002). Synthesis of Dicarboxylate Oligosaccharide Multilayer Terminal Functionality upon Poly(lysine) Dendrimer Scaffolding. J. Polym. Sci. A Polym. Chem., 40, 3622-3633.

13.  Jie Su, Huricha Baigude, Joshua McCarroll and Tariq M. Rana (2011). Silencing microRNA by interfering nanoparticles in mice. Nucleic Acids Research, 39(6), e38, doi:10.1093/nar/gkq1307.

14.  Animesh Ghosh, Koushik Mukherjee, Xinpeng Jiang, Ying Zhou, Joshua McCarroll, James Qu, Pamela M. Swain, Huricha Baigude, and Tariq M. Rana (2010). Design and Assembly of New Nonviral RNAi Delivery Agents by Microwave-Assisted Quaternization (MAQ) of Tertiary Amines.Bioconjugate Chem.21 (9), 1581–1587.

15.  Hongyan Wang, Animesh Ghosh, Huricha Baigude, Chao-shun Yang, Linghua Qiu, Xugang Xia, Hongxia Zhou, Tariq M. Rana and Zuoshang Xu (2008). Therapeutic Gene Silencing Delivered by A Chemically Modified siRNA Against Mutant SOD1 Slows ALS Progression J. Biol. Chem., 283, 15845-15852.

研究成果(发明专利):

  1. 发明创造名称:“一种阳离子脂质类化合物及其制备方法与应用”,专利号:ZL201510228936.4,发明人:胡日查,海小

  2. 发明创造名称:“一种含有二肽类脂质阳离子的化合物及其制备方法与应用”,专利号:ZL201510228170.X,发明人:胡日查,海小

  3. 发明创造名称:“一种基于黑种草的降血糖组合物以及降血糖蒙药”,专利号:ZL201711071958.X,发明人:胡日查,鲍明明

  4. 发明创造名称:“一种阳离子多糖及其制备方法与应用”,专利号:ZL202110263793.6发明人:胡日查,清明

5.  发明创造名称:“一种单糖配体功能化的阳离子脂质类化合物及其制备方法与应用”,申请号:202110553801.0发明人:胡日查,海小